Author:
Wu Zhenyu,Li Patrick,Tian Yuzi,Ouyang Wenlu,Ho Jessie Wai-Yan,Alam Hasan B.,Li Yongqing
Abstract
Peptidylarginine deiminases (PADs) are a group of enzymes that catalyze post-translational modifications of proteins by converting arginine residues into citrullines. Among the five members of the PAD family, PAD2 and PAD4 are the most frequently studied because of their abundant expression in immune cells. An increasing number of studies have identified PAD2 as an essential factor in the pathogenesis of many diseases. The successes of preclinical research targeting PAD2 highlights the therapeutic potential of PAD2 inhibition, particularly in sepsis and autoimmune diseases. However, the underlying mechanisms by which PAD2 mediates host immunity remain largely unknown. In this review, we will discuss the role of PAD2 in different types of cell death signaling pathways and the related immune disorders contrasted with functions of PAD4, providing novel therapeutic strategies for PAD2-associated pathology.
Funder
National Institutes of Health
University of Michigan
Subject
Immunology,Immunology and Allergy
Reference156 articles.
1. Peptidylarginine Deiminases in Citrullination, Gene Regulation, Health and Pathogenesis;Wang;Biochim Biophys Acta,2013
2. PAD, a Growing Family of Citrullinating Enzymes: Genes, Features and Involvement in Disease;Vossenaar;Bioessays,2003
3. Comparative Analysis of the Mouse and Human Peptidylarginine Deiminase Gene Clusters Reveals Highly Conserved non-Coding Segments and a New Human Gene, PADI6;Chavanas;Gene,2004
4. Peptidylarginine Deiminase Expression and Activity in PAD2 Knock-Out and PAD4-Low Mice;van Beers;Biochimie,2013
5. Induction of Protein Citrullination and Auto-Antibodies Production in Murine Exposed to Nickel Nanomaterials;Mohamed;Sci Rep,2018
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