Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

Author:

Wong Wei-Ting,Li Lan-Hui,Rao Yerra Koteswara,Yang Shih-Ping,Cheng Shu-Meng,Lin Wen-Yu,Cheng Cheng-Chung,Chen Ann,Hua Kuo-Feng

Funder

Ministry of Science and Technology, Taiwan

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference49 articles.

1. Beta-blockers: current state of knowledge and perspectives;Ogrodowczyk;Mini Rev Med Chem.,2016

2. Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity;Yang;Cardiovasc Res.,2003

3. Carvedilol suppresses cartilage matrix destruction;Li;Biochem Biophys Res Commun.,2016

4. Carvedilol protects the kidneys of tumor-bearing mice without impairing the biodistribution or the genotoxicity of cisplatin;Carvalho Rodrigues;Chem Biol Interact.,2016

5. Effects of carvedilol on plasma levels of pro-inflammatory cytokines in patients with ischemic and nonischemic dilated cardiomyopathy;Kurum;Tex Heart Inst J.,2007

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