Case Report: Immune Checkpoint Blockade Plus Interferon-Γ Add-On Antifungal Therapy in the Treatment of Refractory Covid-Associated Pulmonary Aspergillosis and Cerebral Mucormycosis-Reference-Cited by-同舟云学术

Case Report: Immune Checkpoint Blockade Plus Interferon-Γ Add-On Antifungal Therapy in the Treatment of Refractory Covid-Associated Pulmonary Aspergillosis and Cerebral Mucormycosis

Published:2022-06-01 Issue: Volume:13 Page:
ISSN:1664-3224
Container-title:Frontiers in Immunology
language:
Short-container-title:Front. Immunol.

Author:

Serris Alexandra,Ouedrani Amani,Uhel Fabrice,Gazzano Marianne,Bedarida Vincent,Rouzaud Claire,Bougnoux Marie-Elisabeth,Raphalen Jean-Herlé,Poirée Sylvain,Lambotte Olivier,Martin-Blondel Guillaume,Lanternier Fanny

Abstract

Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, and new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case of a diabetic patient with refractory IFD following a SARSCoV-2 infection treated by ICI and interferon-gamma associated with antifungal treatment.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference24 articles.

1. T-Cell Invigoration to Tumour Burden Ratio Associated With Anti-PD-1 Response;Huang;Nature,2017

2. Defining « T Cell Exhaustion »;Blank;Nat Rev Immunol,2019

3. Effective Anti-SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders;Rossignol;J Allergy Clin Immunol Pract,2022

4. Characterization of Specific Immune Responses to Different Aspergillus Antigens During the Course of Invasive Aspergillosis in Hematologic Patients;Potenza;PloS One,2013

5. Blockade of the Negative Co-Stimulatory Molecules PD-1 and CTLA-4 Improves Survival in Primary and Secondary Fungal Sepsis;Chang;Crit Care Lond Engl,2013

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