HP-NAP of Helicobacter pylori: The Power of the Immunomodulation-Reference-Cited by-同舟云学术

HP-NAP of Helicobacter pylori: The Power of the Immunomodulation

Published:2022-06-29 Issue: Volume:13 Page:
ISSN:1664-3224
Container-title:Frontiers in Immunology
language:
Short-container-title:Front. Immunol.

Author:

Codolo Gaia,Coletta Sara,D’Elios Mario Milco,de Bernard Marina

Abstract

The miniferritin HP-NAP of Helicobacter pylori was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 responses and revert the immune suppressive profile of macrophages. In this review, we discuss the immune modulating properties of the protein regarding the H. pylori infection and the evidence that support the potential clinical application of HP-NAP in allergy and cancer immunotherapy.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference55 articles.

1. “Iron Storage in Bacteria”;Andrews,1998

2. The Physiological Role of Ferritin-Like Compounds in Bacteria;Smith;Crit Rev Microbiol,2004

3. A Novel DNA-Binding Protein With Regulatory and Protective Roles in Starved Escherichia Coli;Almiron;Genes Dev,1992

4. Protection of DNA During Oxidative Stress by the Nonspecific DNA-Binding Protein Dps;Martinez;J Bacteriol,1997

5. The Peptidoglycan-Associated Protein NapA Plays an Important Role in the Envelope Integrity and in the Pathogenesis of the Lyme Disease Spirochete;Davis;PloS Pathog,2021

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design of a Helicobacter pylori multi-epitope vaccine based on immunoinformatics;Frontiers in Immunology;2024-08-23

2. Candidate Antigens and the Development of Helicobacter pylori Vaccines;Helicobacter;2024-07

3. Interleukin 17 and Interferon-Gamma, Key Cytokines for Inflammation and Diagnosis in Helicobacter pylori and Gastric Malignancies;Towards the Eradication of Helicobacter pylori Infection - Rapid Diagnosis and Precision Treatment;2024-05-15

4. Unveiling the gastric microbiota: implications for gastric carcinogenesis, immune responses, and clinical prospects;Journal of Experimental & Clinical Cancer Research;2024-04-19

5. An intranasal influenza virus vector vaccine protects against Helicobacter pylori in mice;Journal of Virology;2024-03-19