Author:
Yin Jiayi,Zhang Shiming,Yang Chao,Wang Yan,Shi Bing,Zheng Qian,Zeng Ni,Huang Hanyao
Abstract
Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring. Hence, a thorough understanding of the underlying mechanisms is essential in the development of efficacious scar therapeutics. This review provides an overview of the current understanding of the mechanotransduction signaling pathways in scar formation and some strategies that offload mechanical forces in the wounded region for scar prevention and treatment.
Subject
Immunology,Immunology and Allergy
Cited by
13 articles.
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