Author:
Zhong Chi,Liang Geao,Li Peiting,Shi Ke,Li Fuyin,Zhou Jianda,Xu Dan
Abstract
Hyperpigmentation is a common complication in patients with burn injuries during wound healing; however, the mechanisms underlying its occurrence and development remain unclear. Recently, postinflammatory hyperpigmentation (PIH) was found to result from overproduction of melanin. Local or systemic inflammatory responses are often observed in patients who develop hyperpigmentation. However, we lack studies on the relationship between PIH and burn injury. Therefore, we comprehensively reviewed the existing literature on the melanogenesis of the skin, inflammatory mechanisms in pigmentation, and local or systemic alteration in inflammatory cytokines in patients suffering from burn trauma to elucidate the relationship between PIH and burn injury. We believe that this review will guide further research on regulating melanin production in the burn management process.
Subject
Immunology,Immunology and Allergy
Reference124 articles.
1. Burn injury;Jeschke;Nat Rev Dis Primers,2020
2. Restoration of skin pigmentation after deep partial or full-thickness burn injury;Dai;Adv Drug Delivery Rev,2018
3. Postinflammatory hyperpigmentation: Epidemiology, clinical presentation, pathogenesis and treatment;Kaufman;Am J Clin Dermatol,2018
4. Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique;Silpa-Archa;J Am Acad Dermatol,2017
5. Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention;Chaowattanapanit;J Am Acad Dermatol,2017
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