Immunogenicity and protective efficacy of the HC009 mRNA vaccine against SARS-CoV-2

Author:

Liu Juan,Han Huafeng,Yang Binbin,Zhang Naifang,Li Jing,Chen Xicheng,Wu Jie,Zhao Yingying,Yang Yongsheng

Abstract

With the rapid global spread of COVID-19 and the continuous emergence of variants, there is an urgent need to develop safe and effective vaccines. Here, we developed a novel mRNA vaccine, HC009, based on new formulation by the QTsome delivery platform. Immunogenicity results showed that the prime-boost immunization strategy with HC009 was able to induce robust and durable humoral immunity, as well as Th1-biased cellular responses in rodents or non-human primates (NHPs). After further challenge with live SARS-CoV-2 virus, HC009 provided adequate protection against virus infection in hACE2 transgenic mice. Therefore, HC009 could provide significant immune protection against SARS-CoV-2.

Publisher

Frontiers Media SA

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