Author:
Saalbach Anja,Kunz Manfred
Abstract
Psoriasis is a chronic inflammatory disease of the skin and joints associated with several comorbidities such as arthritis, diabetes mellitus and metabolic syndrome, including obesity, hypertension and dyslipidaemia, Crohn’s disease, uveitis and psychiatric and psychological diseases. Psoriasis has been described as an independent risk factor for cardiovascular diseases and thus patients with psoriasis should be monitored for the development of cardiovascular disease or metabolic syndrome. However, there is mounting evidence that psoriasis also affects the development of osteoporosis, an important metabolic disease with enormous clinical and socioeconomic impact. At present, there are still controversial opinions about the role of psoriasis in osteoporosis. A more in depth analysis of this phenomenon is of great importance for affected patients since, until now, bone metabolism is not routinely examined in psoriatic patients, which might have important long-term consequences for patients and the health system. In the present review, we summarize current knowledge on the impact of psoriatic inflammation on bone metabolism and osteoporosis.
Subject
Immunology,Immunology and Allergy
Reference126 articles.
1. Regulation of Bone Metabolism;Shahi;Rep Biochem Mol Biol,2017
2. Function of Soluble RANKL Deciphered;Greenhill;Nat Rev Endocrinol,2019
3. Revisiting Osteoporosis Guidelines;Reid;Lancet Diabetes Endocrinol,2021
4. Disorders of Bone Remodeling;Feng;AnnuRevPathol,2011
5. Aging and Bone Loss: New Insights for the Clinician;Demontiero;TherAdvMusculoskeletDis,2012
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献