Author:
Chen Yihao,Chen Shengpan,Chang Jianbo,Wei Junji,Feng Ming,Wang Renzhi
Abstract
Intracerebral hemorrhage (ICH) has one of the worst prognoses among patients with stroke. Surgical measures have been adopted to relieve the mass effect of the hematoma, and developing targeted therapy against secondary brain injury (SBI) after ICH is equally essential. Numerous preclinical and clinical studies have demonstrated that perihematomal edema (PHE) is a quantifiable marker of SBI after ICH and is associated with a poor prognosis. Thus, PHE has been considered a promising therapeutic target for ICH. However, the findings derived from existing studies on PHE are disparate and unclear. Therefore, it is necessary to classify, compare, and summarize the existing studies on PHE. In this review, we describe the growth characteristics and relevant underlying mechanism of PHE, analyze the contributions of different risk factors to PHE, present the potential impact of PHE on patient outcomes, and discuss the currently available therapeutic strategies.
Funder
Foundation for Innovative Research Groups of the National Natural Science Foundation of China
Chinese Academy of Medical Sciences Initiative for Innovative Medicine
National Key Research and Development Program of China
Huazhong University of Science and Technology
Subject
Immunology,Immunology and Allergy
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