Author:
dos Passos Junior Rinaldo Rodrigues,Bomfim Gisele Facholi,Giachini Fernanda R.,Tostes Rita C.,Lima Victor Vitorino
Abstract
TheO-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins dynamically regulates protein function, localization, stability, and interactions. This post-translational modification is intimately linked to cardiovascular disease, including hypertension. An increasing number of studies suggest that components of innate and adaptive immunity, active players in the pathophysiology of hypertension, are targets for O-GlcNAcylation. In this review, we highlight the potential roles of O-GlcNAcylation in the immune system and discuss how those immune targets of O-GlcNAcylation may contribute to arterial hypertension.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Subject
Immunology,Immunology and Allergy
Cited by
3 articles.
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