Author:
Wei Xiya,Xie Yiyu,Jiang Ruoyu,Li Huiyu,Wu Heqing,Zhang Yuqi,Li Ling,Zhou Shiyuan,Ma Xiao,Tang Zaixiang,He Jun,Wu Depei,Wu Xiaojin
Abstract
Rituximab is used to eliminate B cells as a chimeric monoclonal antibody directed against CD20, a B-cell antigen expressed on B cells. To explore the impact of rituximab administered before transplantation, we implemented a retrospective, monocentric study and utilized real-world data collected at our center between January 2018 and December 2020, and then followed until December 2021. Based on whether a dose of 375mg/m2 rituximab was used at least once within two weeks before transplantation, patients undergoing allo-HSCT were classified into two groups: rituximab (N=176) and non-rituximab (N=344) group. Amongst all the patients, the application of rituximab decreased EBV reactivation (P<0.01) and rituximab was an independent factor in the prevention of EBV reactivation by both univariate and multivariate analyses (HR 0.56, 95%CI 0.33-0.97, P=0.04). In AML patients, there were significant differences in the cumulative incidence of aGVHD between the two groups (P=0.04). Our data showed that rituximab was association with a decreased incidence of aGVHD in AML patients according to both univariate and multivariate analyses. There was no difference between the two groups in other sets of populations. Thus, our study indicated that rituximab administered before transplantation may help prevent EBV reactivation in all allo-HSCT patients, as well as prevent aGVHD in AML patients after allo-HSCT.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Science and Technology Program of Suzhou
National Major Science and Technology Projects of China
National Key Research and Development Program of China
Priority Academic Program Development of Jiangsu Higher Education Institutions
Jiangsu Province's Key Provincial Talents Program
Key Medical Subjects of Jiangsu Province
Subject
Immunology,Immunology and Allergy
Cited by
7 articles.
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