Author:
Androutsakos Theodoros,Voulgaris Theodoros A.,Bakasis Athanasios-Dimitrios,Koutsompina Maria-Loukia,Chatzis Loukas,Argyropoulou Ourania D.,Pezoulas Vasilis,Fotiadis Dimitrios I.,Papatheodoridis George,Tzioufas Athanasios G.,Goules Andreas V.
Abstract
BackgroundPrimary Sjögren syndrome (pSS) is a systemic autoimmune epithelitis, potentially affecting salivary epithelium, biliary epithelium, and hepatocytes. Common immunological mechanisms might cause clinically silent liver inflammation, and combined with non-alcoholic fatty liver disease (NAFLD), liver fibrosis (LF) may occur. No studies have explored the occurrence of LF in the context of NAFLD among pSS patients.MethodsConsecutive pSS patients from the rheumatology outpatient clinic of the Department of Pathophysiology and individuals evaluated in the hepatology outpatient clinic for possible NAFLD serving as comparators underwent transient elastography (TE) to assess LF and liver steatosis (LS). All participants had no overt chronic liver disease. Clinical, demographic, and laboratory data were collected from all participants at the time of TE.ResultsFifty-two pSS patients and 198 comparators were included in the study. The median age (range) of pSS and comparators was 62.5 (30–81) and 55 (19–86) years, respectively. Both groups had similar prevalence regarding type 2 diabetes mellitus, hyperlipidemia, and similar body mass index (BMI). Patients with pSS had less frequently high LS (S2, S3) (27% vs. 62%, p < 0.001) and significant LF (F2–4) [2 (3.8%) vs. 34 (17.2%), p = 0.014] than comparators. Univariable analysis showed that advanced LF was significantly associated with older age, higher LS, greater BMI, and disease status (comparators than pSS); of these, only age was identified as an independent LF risk factor in the multivariable logistic regression analysis.ConclusionLiver fibrosis among pSS patients is most likely not attributed to the disease per se.
Subject
Immunology,Immunology and Allergy
Reference38 articles.
1. Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes;Younossi;Hepatology,2016
2. Prevalence, Incidence, and Outcome of Non-Alcoholic Fatty Liver Disease in Asia, 1999-2019: A Systematic Review and Meta-Analysis;Li;Lancet Gastroenterol Hepatol,2019
3. 2019 Global Nafld Prevalence: A Systematic Review and Meta-Analysis;Le;Clin Gastroenterol Hepatol,2021
4. Prevalence of Nafld, Mafld and Associated Advanced Fibrosis in the Contemporary United States Population;Ciardullo;Liver Int,2021
5. Nonalcoholic Steatohepatitis: A Review;Sheka;JAMA,2020
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献