Author:
Xu Xiaoyu,Wang Miao,Wang Zikang,Chen Qian,Chen Xixuan,Xu Yingyue,Dai Min,Wu Bin,Li Yanping
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction, synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic effects on gut homeostasis. It may trigger the host’s innate immune system and activate the “gut–joint axis”, which exacerbates the RA. However, although the importance of the gut microbiota in the development and progression of RA is widely recognized, the mechanisms regulating the interactions between the gut microbiota and the host immune system remain incompletely defined. In this review, we discuss the role of gut microbiota-derived biological mediators, such as short-chain fatty acids, bile acids, and tryptophan metabolites, in maintaining intestinal barrier integrity, immune balance and bone destruction in RA patients as the bridge of the gut–joint axis.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Chongqing
Chengdu University of Traditional Chinese Medicine
Subject
Immunology,Immunology and Allergy
Cited by
13 articles.
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