Author:
Zhao Qihan,Dai Haoran,Liu Xianli,Jiang Hanxue,Liu Wenbin,Feng Zhendong,Zhang Na,Gao Yu,Dong Zhaocheng,Zhou Xiaoshan,Du Jieli,Zhang Naiqian,Rui Hongliang,Yuan Li,Liu Baoli
Abstract
Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the immune system produces an antibody response to its own antigens due to impaired immune tolerance. Although antibodies are derived from plasma cells differentiated by B cells, the T-B cells also contribute a lot to the immune system. In particular, the subsets of helper T (Th) cells, including the dominant subsets such as Th2, Th17, and follicular helper T (Tfh) cells and the inferior subsets such as regulatory T (Treg) cells, shape the immune imbalance of IMN and promote the incidence and development of autoimmune responses. After reviewing the physiological knowledge of various subpopulations of Th cells and combining the existing studies on Th cells in IMN, the role model of Th cells in IMN was explained in this review. Finally, the existing clinical treatment regimens for IMN were reviewed, and the importance of the therapy for Th cells was highlighted.
Funder
National Key Research and Development Program of China
Natural Science Foundation of Beijing Municipality
Subject
Immunology,Immunology and Allergy
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献