From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

Author:

Khawar Muhammad Babar,Ge Fei,Afzal Ali,Sun Haibo

Abstract

Chimeric antigen receptor (CAR) T cell therapy for solid tumors shows promise, but several hurdles remain. Strategies to overcome barriers such as CAR T therapy-related toxicities (CTT), immunosuppression, and immune checkpoints through research and technology are needed to put the last nail to the coffin and offer hope for previously incurable malignancies. Herein we review current literature and infer novel strategies for the mitigation of CTT while impeding immune suppression, stromal barriers, tumor heterogeneity, on-target/off-tumor toxicities, and better transfection strategies with an emphasis on clinical research and prospects.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Targeting Tumors;Advances in Medical Diagnosis, Treatment, and Care;2024-08-28

2. Steering the course of CAR T cell therapy with lipid nanoparticles;Journal of Nanobiotechnology;2024-06-28

3. CAR T Therapies: Game Changer or Culprit in Cancer Treatment?‎;Albus Scientia;2024-03-05

4. Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy;International Journal of Molecular Sciences;2023-09-28

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