Author:
He Xiang-Ning,Zeng Zhen-Zhen,Wu Pei,Jiang Wei-Dan,Liu Yang,Jiang Jun,Kuang Sheng-Yao,Tang Ling,Feng Lin,Zhou Xiao-Qiu
Abstract
Aflatoxin B1 (AFB1) is kind of a common mycotoxin in food and feedstuff. Aquafeeds are susceptible to contamination of AFB1. In teleost fish, the spleen and head kidney are key immune organ. Moreover, the fish skin is a critical mucosal barrier system. However, there was little study on the effects of dietary AFB1 on the immune response of these immune organs in fish. This study aimed to explore the impacts of oral AFB1 on the immune competence and its mechanisms in the skin, spleen, and head kidney of grass carp. Our work indicated that dietary AFB1 reduced antibacterial compounds and immunoglobulins contents, and decreased the transcription levels of antimicrobial peptides in grass carp immune organs. In addition, dietary AFB1 increased the transcription levels of pro-inflammatory cytokines and reduced the transcription levels of anti-inflammatory cytokines in the grass carp immune organs, which might be regulated by NF-κB and TOR signaling, respectively. Meanwhile, we evaluated the content of AFB1 in the grass carp diet should not exceed 29.48 μg/kg diet according to the levels of acid phosphatase and lysozyme. In summary, dietary AFB1 impaired immune response in grass carp skin, spleen, and head kidney.
Funder
National Key Research and Development Program of China
National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
Sichuan Province Science and Technology Support Program
Earmarked Fund for China Agriculture Research System
Subject
Immunology,Immunology and Allergy
Cited by
4 articles.
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