Exploring the causal role of gut microbiota in giant cell arteritis: a Mendelian randomization analysis with mediator insights

Author:

Wu Menglin,Liao Zhixiong,Zeng Kaidong,Jiang Qiaohui

Abstract

BackgroundGiant Cell Arteritis (GCA) is a complex autoimmune condition. With growing interest in the role of gut microbiota in autoimmune diseases, this research aimed to explore the potential causal relationship between gut microbiota and GCA, and the mediating effects of specific intermediaries.MethodsUsing a bidirectional two-sample Mendelian randomization (MR) design, we investigated associations between 191 microbial taxa and GCA. A two-step MR technique discerned the significant mediators on this relationship, followed by Multivariable MR analyses to quantify the direct influence of gut microbiota on GCA and mediation effect proportion, adjusting for these mediators.ResultsNine taxa displayed significant associations with GCA. Among them, families like Bacteroidales and Clostridiaceae1 had Odds Ratios (OR) of 1.48 (p=0.043) and 0.52 (p=5.51e-3), respectively. Genera like Clostridium sensu stricto1 and Desulfovibrio showed ORs of 0.48 (p=5.39e-4) and 1.48 (p=0.037), respectively. Mediation analyses identified 25 hydroxyvitamin D level (mediation effect of 19.95%), CD14+ CD16- monocyte counts (mediation effect of 27.40%), and CD4+ T cell counts (mediation effect of 28.51%) as significant intermediaries.ConclusionOur findings provide invaluable insights into the complex interplay between specific gut microbiota taxa and GCA. By highlighting the central role of gut microbiota in influencing GCA risk and long-term recurrence, and their interactions with vital immune mediators, this research paves the way for potential therapeutic interventions in GCA management.

Publisher

Frontiers Media SA

Reference59 articles.

1. Temporal arteritis AmeerMA PeterfyRJ KhazaeniB Treasure Island (FLStatPearls PublishingStatPearls2023

2. Prognosis of giant cell arteritis including temporal arteritis and polymyalgia rheumatica. A follow-up study on ninety patients treated with corticosteroids;Bengtsson;Acta Med Scand,1981

3. Giant cell arteritis and mortality;Crow;J Gerontol A Biol Sci Med Sci,2009

4. Th17 and Th1 T-cell responses in giant cell arteritis;Deng;Circulation,2010

5. The immunopathology of giant cell arteritis: diagnostic and therapeutic implications;Weyand;J Neuroophthalmol,2012

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