One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia-Reference-Cited by-同舟云学术

One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia

Published:2021-04-01 Issue: Volume:12 Page:
ISSN:1664-3224
Container-title:Frontiers in Immunology
language:
Short-container-title:Front. Immunol.

Author:

Wang Zhiding,Chen Jinghong,Wang Mengzhen,Zhang Linlin,Yu Li

Abstract

T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions make Tim-3 a potential target for curing AML. This review mainly discusses the roles of Tim-3 in the immune system in AML and as an AML LSC marker, which sheds new light on the role of Tim-3 in AML immunotherapy.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference71 articles.

1. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease;Monney;Nature,2002

2. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family;McIntire;Nat Immunol,2001

3. The TIM gene family regulates autoimmune and allergic diseases;Meyers;Trends Mol Med,2005

4. TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression;Gao;PloS One,2012

5. Hypothesis: Tim-3/galectin-9, a new pathway for leukemia stem cells survival by promoting expansion of myeloid-derived suppressor cells and differentiating into tumor-associated macrophages;Gao;Cell Biochem Biophys,2014

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Anti-TIM3 chimeric antigen receptor-natural killer cells preferentially target primitive acute myeloid leukemia cells with minimal fratricide and exhaustion;Experimental Hematology & Oncology;2024-07-11

2. Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors;ACS Medicinal Chemistry Letters;2024-05-28

3. AML treatment: conventional chemotherapy and emerging novel agents;Trends in Pharmacological Sciences;2024-05

4. TCR β chain repertoire characteristic between healthy human CD4+ and CD8+ T cells;Bioscience Reports;2024-03

5. A T-cell receptor as a promising immunotherapeutic target in acute myeloid leukemia: expression of T cell immunoglobulin and mucin-containing-3 on bone marrow hematopoietic cells;The Egyptian Journal of Haematology;2024-01