Author:
Beicht Jana,Kubinski Mareike,Zdora Isabel,Puff Christina,Biermann Jeannine,Gerlach Thomas,Baumgärtner Wolfgang,Sutter Gerd,Osterhaus Albert D. M. E.,Prajeeth Chittappen Kandiyil,Rimmelzwaan Guus F.
Abstract
IntroductionTick-borne encephalitis virus (TBEV) is one of the most relevant tick-transmitted neurotropic arboviruses in Europe and Asia and the causative agent of tick-borne encephalitis (TBE). Annually more than 10,000 TBE cases are reported despite having vaccines available. In Europe, the vaccines FSME-IMMUN® and Encepur® based on formaldehyde-inactivated whole viruses are licensed. However, demanding vaccination schedules contribute to sub-optimal vaccination uptake and breakthrough infections have been reported repeatedly. Due to its immunogenic properties as well as its role in viral replication and disease pathogenesis, the non-structural protein 1 (NS1) of flaviviruses has become of interest for non-virion based flavivirus vaccine candidates in recent years.MethodsTherefore, immunogenicity and protective efficacy of TBEV NS1 expressed by neuraminidase (NA)-deficient Influenza A virus (IAV) or Modified Vaccinia virus Ankara (MVA) vectors were investigated in this study.ResultsWith these recombinant viral vectors TBEV NS1-specific antibody and T cell responses were induced. Upon heterologous prime/boost regimens partial protection against lethal TBEV challenge infection was afforded in mice.DiscussionThis supports the inclusion of NS1 as a vaccine component in next generation TBEV vaccines.
Funder
Alexander von Humboldt-Stiftung
Deutsche Forschungsgemeinschaft
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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