Ocular Motor Abnormalities in Anti-IgLON5 Disease

Author:

Macher Stefan,Milenkovic Ivan,Zrzavy Tobias,Höftberger Romana,Seidel Stefan,Berger-Sieczkowski Evelyn,Berger Thomas,Rommer Paulus S.,Wiest Gerald

Abstract

ObjectiveAnti-IgLON5 disease forms an interface between neuroinflammation and neurodegeneration and includes clinical phenotypes that are often similar to those of neurodegenerative diseases. An early diagnosis of patients with anti-IgLON5 disease and differentiation from neurodegenerative diseases is necessary and may have therapeutic implications.MethodsIn our small sample size study we investigated oculomotor function as a differentiating factor between anti-IgLON5 disease and neurodegenerative disorders. We examined ocular motor and vestibular function in four patients suffering from anti-IgLON5 disease using video-oculography (VOG) and a computer-controlled rotational chair system (sampling rate 60 Hz) and compared the data with those from ten age-matched patients suffering from progressive supranuclear palsy (PSP) and healthy controls (CON).ResultsPatients suffering from anti-IgLON5 disease differed from PSP most strikingly in terms of saccade velocity and accuracy, the presence of square wave jerks (SWJ) (anti-IgLON5 0/4 vs. PSP 9/10) and the clinical finding of supranuclear gaze palsy (anti-IgLON5 1/4). The presence of nystagmus, analysis of smooth pursuit eye movements, VOR and VOR suppression was reliable to differentiate between the two disease entities. Clear differences in all parameters, although not always significant, were found between all patients and CON.DiscussionWe conclude that the use of VOG as a tool for clinical neurophysiological assessment can be helpful in differentiating between patients with PSP and patients with anti-IgLON5 disease. VOG could have particular value in patients with suspected PSP and lack of typical Parkinson’s characteristics. future trials are indispensable to assess the potential of oculomotor function as a biomarker in anti-IgLON5 disease.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. PSP-Richardson syndrome mimics: An overview and pragmatic approach;Revue Neurologique;2024-01

2. Neuro-ophthalmic manifestations of autoimmune disorders: diagnostic pearls & pitfalls;Current Opinion in Ophthalmology;2023-09-20

3. “Zickzackbewegungen”;Advances in Ophthalmology and Optometry;2023-08

4. Pathogenesis, clinical features and treatment of anti‐IgLON5 disease;Clinical and Experimental Neuroimmunology;2023-07-06

5. Anti-IgLON5 disease: a novel topic beyond neuroimmunology;Neural Regeneration Research;2023

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