Author:
Gallerani Eleonora,Proietto Davide,Dallan Beatrice,Campagnaro Marco,Pacifico Salvatore,Albanese Valentina,Marzola Erika,Marconi Peggy,Caputo Antonella,Appay Victor,Gavioli Riccardo,Nicoli Francesco
Abstract
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses.
Funder
Ludwig-Maximilians-Universität München
Subject
Immunology,Immunology and Allergy
Cited by
18 articles.
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