Author:
Paprckova Darina,Niederlova Veronika,Moudra Alena,Drobek Ales,Pribikova Michaela,Janusova Sarka,Schober Kilian,Neuwirth Ales,Michalik Juraj,Huranova Martina,Horkova Veronika,Cesnekova Michaela,Simova Michaela,Prochazka Jan,Balounova Jana,Busch Dirk H.,Sedlacek Radislav,Schwarzer Martin,Stepanek Ondrej
Abstract
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8+ T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naïve monoclonal CD8+ T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.
Funder
Grantová Agentura České Republiky
Akademie Věd České Republiky
Grantová Agentura, Univerzita Karlova
Ministerstvo Školství, Mládeže a Tělovýchovy
Deutsche Forschungsgemeinschaft
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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