Author:
Cioccarelli Chiara,Sánchez-Rodríguez Ricardo,Angioni Roberta,Venegas Francisca C.,Bertoldi Nicole,Munari Fabio,Cattelan Annamaria,Molon Barbara,Viola Antonella
Abstract
After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted.
Funder
Fondazione Cassa di Risparmio di Padova e Rovigo
Fondazione Città della Speranza
Subject
Immunology,Immunology and Allergy
Cited by
19 articles.
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