Author:
Wroński Jakub,Jaszczyk Bożena,Roszkowski Leszek,Felis-Giemza Anna,Bonek Krzysztof,Kornatka Anna,Plebańczyk Magdalena,Burakowski Tomasz,Lisowska Barbara,Kwiatkowska Brygida,Maśliński Włodzimierz,Wisłowska Małgorzata,Massalska Magdalena,Ciechomska Marzena,Kuca-Warnawin Ewa
Abstract
IntroductionPrevious studies have shown a reduction in the effectiveness of primary COVID-19 vaccination in patients with rheumatic diseases. However, limited data is available regarding the effectiveness of the COVID-19 vaccine booster dose, especially on cellular response. The study aimed to assess the humoral and cellular immunogenicity of a booster dose in patients with inflammatory arthritis (IA).Patients and methods49 IA and 47 age and sex-matched healthy controls (HC) were included in a prospective cohort study. Both groups completed primary COVID-19 vaccination and after more than 180 days received a BNT162b2 booster shot. Humoral responses (level of IgG antibodies) and cellular responses (IFN-γ production) were assessed before and after 4 weeks from the booster dose of the vaccine.ResultsAfter the booster dose, all participants showed an increased humoral response, although significantly reduced antibody levels were observed in IA patients compared to HC (p=0.004). The cellular response was significantly lower both before (p<0.001) and after (p<0.001) the booster dose in IA patients as compared to HC. Among the immunomodulatory drugs, only biological and targeted synthetic drugs lowered the humoral response after booster vaccination. However, the cellular response was decreased after all immunomodulatory drugs except IL-17 inhibitors and sulfasalazine.ConclusionOur data indicate that patients with rheumatic diseases present lower humoral and cellular responses after the COVID-19 booster vaccine in comparison to HC. This may translate into a recommendation for subsequent booster doses of the COVID-19 vaccine for rheumatic patients.
Funder
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. dr hab. med. Eleonory Reicher
Subject
Immunology,Immunology and Allergy
Cited by
7 articles.
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