Author:
Taylor Andrew W.,Hsu Samuel,Ng Tat Fong
Abstract
The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cells (RPE) regulate the activity of immune cells within the retina. These mechanisms involve the expression of immunomodulating molecules that make macrophages and microglial cells suppress inflammation and promote immune tolerance. The RPE have an important role in ocular immune privilege to regulate the behavior of immune cells within the retina. Reviewed is the current understanding of how RPE mediate this regulation and the changes seen under pathological conditions.
Funder
National Eye Institute
Massachusetts Lions Eye Research Fund
Subject
Immunology,Immunology and Allergy
Reference118 articles.
1. Immunity to Homologous Grafted Skin. III. The Fate of Skin Homografts Transplanted to the Brain to Subcutaneous Tissue, and to the Anterior Chamber of the Eye;Medawar;Br J Exp Pathol,1948
2. Ocular Immune Privilege in the Year 2010: Ocular Immune Privilege and Uveitis;Taylor;Ocul Immunol Inflamm,2010
3. Ocular Immune Privilege;Taylor;Eye (Lond),2009
4. CNS Infection and Immune Privilege;Forrester;Nat Rev Neurosci,2018
5. Negative Regulators That Mediate Ocular Immune Privilege;Taylor;J Leukoc Biol,2018
Cited by
35 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献