Author:
Nückel Julius,Planatscher Elisa,Mohr Anne Wiebe,Deichl Karolin,Mijočević Hrvoje,Feuerherd Martin,Wolff Lisa,Erber Johanna,Schneider Jochen,Quante Michael,Winter Christoph,Ruland Jürgen,Hapfelmeier Alexander,Hammerschmidt Wolfgang,Moosmann Andreas,Protzer Ulrike,Behrends Uta,Mautner Josef
Abstract
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.
Subject
Immunology,Immunology and Allergy
Cited by
3 articles.
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