Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection
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Published:2023-07-27
Issue:
Volume:14
Page:
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ISSN:1664-3224
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Container-title:Frontiers in Immunology
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language:
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Short-container-title:Front. Immunol.
Author:
Curtiss Miranda L.,Rosenberg Alexander F.,Scharer Christopher D.,Mousseau Betty,Benavides Natalia A. Ballesteros,Bradley John E.,León Beatriz,Steele Chad,Randall Troy D.,Lund Frances E.
Abstract
IntroductionData from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.MethodsTo address whether Chi3l1 also contributes to TH2 responses following nematode infection, we infected Chi3l1-/- mice with Heligmosomoides polygyrus (Hp) and analyzed T cell responses.ResultsAs anticipated, we observed impaired TH2 responses in Hp-infected Chi3l1-/- mice. However, we also found that T cell intrinsic expression of Chi3l1 was required for ICOS upregulation following activation of naïve CD4 T cells and was necessary for the development of the IL-4+ TFH subset, which supports germinal center B cell reactions and IgE responses. We also observed roles for Chi3l1 in TFH, germinal center B cell, and IgE responses to alum-adjuvanted vaccination. While Chi3l1 was critical for IgE humoral responses it was not required for vaccine or infection-induced IgG1 responses.DiscussionThese results suggest that Chi3l1 modulates IgE responses, which are known to be highly dependent on IL-4-producing TFH cells.
Funder
American Lung Association
National Institutes of Health
University of Alabama at Birmingham
Publisher
Frontiers Media SA
Subject
Immunology,Immunology and Allergy
Cited by
1 articles.
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