Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision

Author:

Adair Patrick R.,Kim Yong Chan,Zhang Ai-Hong,Yoon Jeongheon,Scott David W.

Funder

National Institutes of Health

National Multiple Sclerosis Society

Pfizer

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference108 articles.

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2. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases;Sakaguchi;J Immunol,1995

3. The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery;Sakaguchi;J Clin Invest,2003

4. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells;Fontenot;Nat Immunol,2003

5. Defective regulatory and effector T cell functions in patients with FOXP3 mutations;Bacchetta;J Clin Invest,2006

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