Author:
da Silva Juliana Virginio,Moreira Carla Cristina,Montija Elisandra de Almeida,Feitosa Karina Alves,Correia Ricardo de Oliveira,Domingues Nelson Luis de Campos,Soares Edson Garcia,Allegretti Silmara Marques,Afonso Ana,Anibal Fernanda de Freitas
Abstract
IntroductionThe trematode Schistosoma mansoni causes schistosomiasis, and this parasite’s life cycle depends on the mollusk Biomphalaria glabrata. The most effective treatment for infected people is administering a single dose of Praziquantel. However, there are naturally resistant to treatment. This work has developed, considering this parasite’s complex life cycle.MethodsThe synthetics compound were evaluated: i) during the infection of B. glabrata, ii) during the infection of BALB/c mice, and iii) during the treatment of mice infected with S. mansoni.Results and DiscussionFor the first objective, snails infected with miracidia treated with compounds C1 and C3 at concentrations of 25% IC50 and 50% IC50, after 80 days of infection, released fewer cercariae than the infected group without treatment. For the second objective, compounds C1 and C3 did not show significant results in the infected group without treatment. For the third objective, the mice treated with C3 and C1 reduced the global and differential cell count. The results suggest that although the evaluated compounds do not present schistosomicidal properties when placed in cercariae suspension, they can stimulate an immune reaction in snails and decrease mice’s inflammatory response. In general, we can conclude that compound C1 and C3 has an anti-schistosomicidal effect both in the larval phase (miracidia) and in the adult form of the parasite.
Subject
Immunology,Immunology and Allergy
Reference66 articles.
1. Molluscicidal and cercaricidal activities of curcumin on biomphalaria glabrata and schistosoma mansoni cercariae;Matos;Pest Manag Sci,2020
2. Schistosomiasis: Life cycle, diagnosis, and control;Nelwan;Curr Ther Res - Clin Exp,2019
3. Schistosomiasis in immigrants, refugees and travellers in an Italian referral centre for tropical diseases;Marchese;Infect Dis Poverty,2018
4. Study of diagnostic accuracy of helmintex, kato-Katz, and POC-CCA methods for diagnosing intestinal schistosomiasis in candeal, a low intensity transmission area in northeastern Brazil;Lindholz;PloS Negl Trop Dis,2018
5. Compatibility polymorphism based on long-term host-parasite relationships: Cross talking between biomphalaria glabrataand the trematode schistosoma mansoni from endemic areas in Brazil;Lima;Front Immunol,2019