The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients

Author:

Arnaud Marion,Bobisse Sara,Chiffelle Johanna,Harari Alexandre

Abstract

Mutation-derived neoantigens are now established as attractive targets for cancer immunotherapy. The field of adoptive T cell transfer (ACT) therapy was significantly reshaped by tumor neoantigens and is now moving towards the genetic engineering of T cells with neoantigen-specific T cell receptors (TCRs). Yet, the identification of neoantigen-reactive TCRs remains challenging and the process needs to be adapted to clinical timelines. In addition, the state of recipient T cells for TCR transduction is critical and can affect TCR-ACT efficacy. Here we provide an overview of the main strategies for TCR-engineering, describe the selection and expansion of optimal carrier cells for TCR-ACT and discuss the next-generation methods for rapid identification of relevant TCR candidates for gene transfer therapy.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Biltema Foundation

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

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