Pyroptosis in development, inflammation and disease

Author:

Pan Yuhong,Cai Wenjun,Huang Juan,Cheng Anchun,Wang Mingshu,Yin Zhongqiong,Jia Renyong

Abstract

In the early 2000s, caspase-1, an important molecule that has been shown to be involved in the regulation of inflammation, cell survival and diseases, was given a new function: regulating a new mode of cell death that was later defined as pyroptosis. Since then, the inflammasome, the inflammatory caspases (caspase-4/5/11) and their substrate gasdermins (gasdermin A, B, C, D, E and DFNB59) has also been reported to be involved in the pyroptotic pathway, and this pathway is closely related to the development of various diseases. In addition, important apoptotic effectors caspase-3/8 and granzymes have also been reported to b involved in the induction of pyroptosis. In our article, we summarize findings that help define the roles of inflammasomes, inflammatory caspases, gasdermins, and other mediators of pyroptosis, and how they determine cell fate and regulate disease progression.

Funder

National Natural Science Foundation of China

Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System

Basic Research Programs of Sichuan Province

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

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