Organ complications after CD19 CAR T-cell therapy for large B cell lymphoma: a retrospective study from the EBMT transplant complications and lymphoma working party

Author:

Penack Olaf,Peczynski Christophe,Koenecke Christian,Polge Emmanuelle,Sanderson Robin,Yakoub-Agha Ibrahim,Fegueux Nathalie,Daskalakis Michael,Collin Matthew,Dreger Peter,Kröger Nicolaus,Schanz Urs,Bloor Adrian,Ganser Arnold,Besley Caroline,Wulf Gerald G.,Novak Urban,Moiseev Ivan,Schoemans Hélène,Basak Grzegorz W.,Chabannon Christian,Sureda Anna,Glass Bertram,Peric Zinaida

Abstract

We investigated ≥ grade 3 (CTC-AE) organ toxicities for commercial CD19 chimeric antigen receptor T cell (CAR-T cell) products in 492 patients (Axi-Cel; n = 315; Tisa-Cel; n = 177) with Large B-cell Lymphoma in the European Society for Blood and Marrow Transplantation (EBMT) CAR-T registry. The incidence of ≥ grade 3 organ toxicities during the first 100 days after CAR-T was low and the most frequent were: renal (3.0%), cardiac (2.3%), gastro-intestinal (2.3%) and hepatic (1.8%). The majority occurred within three weeks after CAR-T cell therapy. Overall survival was 83.1% [79.8-86.5; 95% CI] at 3 months and 53.5% [49-58.4; 95% CI] at one year after CAR-T. The most frequent cause of death was tumour progression (85.1%). Non-relapse mortality was 3.1% [2.3-4.1; 95% CI] at 3 months and 5.2% [4.1-6.5; 95% CI] at one year after CAR-T. The most frequent causes of non-relapse mortality were cell-therapy-related toxicities including organ toxicities (6.4% of total deaths) and infections (4.4% of total deaths). Our data demonstrates good safety in the European real-world setting.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

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