Author:
Tian Ye,Chong Xiao-Meng,Liu Ying,Han Ying,Hu Chang-Qin,Yao Shang-chen,Xu Ming-Zhe
Abstract
In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that neither of the isomeric impurities was embryotoxic. This study provides a reference for the production, storage, and quality control of cefotiam and related cephalosporin antibiotics.
Cited by
1 articles.
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