Author:
Chen Bing,Chu Chengchao,Ren En,Lin Huirong,Zhang Yang,Wang Peiyu,Yao Hong,Liu Ailin,Liu Gang,Lin Xinhua
Abstract
Metal-ion-based self-assembly supramolecular theranostics exhibit excellent performance in biomedical applications owing to their potential superiorities for simultaneous precise diagnosis, targeted drug delivery, and monitoring the response to therapy in real-time. Specially, the rational designed systems could achieve specific in vivo self-assembly through complexation or ionic interaction to improve tissue-specific accumulation, penetration, and cell internalization, thereby reducing toxicities of drugs in diagnostics and therapy. Furthermore, such imaging traceable nanosystems could provide real-timely information of drug accumulation and therapeutic effects in a non-invasive and safe manner. Herein, the article highlights the recent prominent applications based on the metal ions self-assembly in cancer treatment. This strategy may open up new research directions to develop novel drug delivery systems for cancer theranostics.
Funder
Major State Basic Research Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Fujian Province
Cited by
4 articles.
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