1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents-Reference-Cited by-同舟云学术

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents

Published:2022-01-21 Issue: Volume:9 Page:
ISSN:2296-2646
Container-title:Frontiers in Chemistry
language:
Short-container-title:Front. Chem.

Author:

Anthwal Tulika,Nain Sumitra

Abstract

A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial. To date, drugs such as butazolamide, and acetazolamide. Several modifications have been done in the 1,3,4-thiadiazole moiety which showed good potency as anticonvulsant agents which are highly effective and have less toxicity. After in-depth literature survey in this review, we have compiled various derivatives of 1,3,4-thiadiazole scaffold as anticonvulsant agents.

Publisher

Frontiers Media SA

Subject

General Chemistry

Reference76 articles.

1. Design, Synthesis, and In-Vivo Anticonvulsant Evaluation of 5-[(E)-(3, 4, 5-trimethoxybenzylidene) Amino]-1, 3, 4-Thiadiazole-2-Thiol;Aliyu;IJSGS,2021

2. Synthesis, Anticonvulsant, and Muscle Relaxant Activities of Substituted 1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole, and 1, 2, 4-triazole;Almasirad;Acta Chim. Slow,2007

3. Anticonvulsant Activities of Some Novel 3-[5-substituted, 3, 4-Thiadiazole-Yl]-2-Styryl Quinazoline-4 (3h)-Ones;Bhandari;Pharmacologyonline,2008

4. Design, Synthesis, and Anticonvulsant Potential of (E)-3-(5-(substituted Aminomethyl)-1, 3, 4-Thiadiazol-2-Yl)-2-Substituted Styrylquinazolin-4-(3h)-One;Bhattacharya;J. Drug Deliv. Ther.,2019

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