Author:
Jakob Bastian,Diehl Andreas M.,Horst Kathrin,Kelm Harald,Manolikakes Georg
Abstract
A palladium-catalyzed asymmetric three-component synthesis ofα-arylglycine derivatives starting from glyoxylic acid, sulfonamides and arylboronic acids is reported. This novel, operationally simple method offers access to theα-arylglycine scaffold in good yields and enantioselectivities. The utilization of α tailored catalyst system enables the enantioselective synthesis of the desiredα-arylglycines despite a fast racemic background reaction. The obtained products can be directly employed as building blocks in peptide synthesis.
Cited by
1 articles.
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