Author:
Kuriyama Yuse,Sasano Yusuke,Iwabuchi Yoshiharu
Abstract
Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups.
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development