Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra-Reference-Cited by-同舟云学术

Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra

Published:2021-03-30 Issue: Volume:9 Page:
ISSN:2296-2646
Container-title:Frontiers in Chemistry
language:
Short-container-title:Front. Chem.

Author:

Zhang Bingyang,Liu Di,Ji Wenyue,Otsuki Kouharu,Higai Koji,Zhao Feng,Li Wei,Koike Kazuo,Qiu Feng

Abstract

Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.

Publisher

Frontiers Media SA

Subject

General Chemistry

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