Analysis of associations between the TLR3 SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil

Author:

Silva Marcos Jessé Abrahão,Vieira Marcelo Cleyton da Silva,Souza Alex Brito,Santos Everaldina Cordeiro dos,Marcelino Beatriz dos Reis,Casseb Samir Mansour Moraes,Lima Karla Valéria Batista,Lima Luana Nepomuceno Gondim Costa

Abstract

The objective of this article was to verify associations between the SNPs rs3775291 (Cytosine [C]>Thymine [T]) and rs3775290 (C>T) of TLR3 in professionals from Health Institutions (HI) who worked during the first pandemic wave and COVID-19. A case-control study was carried out with workers from HI in Belém-PA, Brazil, divided into symptomatology groups (Asymptomatic-AS, n=91; and Symptomatic-SI, n=121), and severity groups, classified by Chest CT scan (symptomatic with lung involvement – SCP, n=34; symptomatic without lung involvement – SSP, n=8). Genotyping was performed by Sanger sequencing and statistical analysis was performed using the SPSS program. In the analysis of SNP rs3775291, the homozygous recessive genotype (T/T) was not found and the frequency of the mutant allele (T) was less than 2% in the cohort. For the rs3775290 SNP, the frequency of the mutant allele (T) was greater than 42% in the cohort. No significant associations were found for these SNPs in this cohort (N= 212 individuals). The scientific community and physicians can use these facts to find new methods of managing COVID-19.

Funder

CoordenaÇão de AperfeiÇoamento de Pessoal de Nível Superior

Publisher

Frontiers Media SA

Subject

Infectious Diseases,Microbiology (medical),Immunology,Microbiology

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