Author:
Umana Giuseppe E.,Tomasi S. Ottavio,Palmisciano Paolo,Scalia Gianluca,Da Ros Valerio,Al-Schameri Rahman,Priola Stefano M.,Brunasso Lara,Giammalva Giuseppe Roberto,Paolini Federica,Costanzo Roberta,Bonosi Lapo,Gerardi Rosa Maria,Maugeri Rosario,Strigari Lidia,Stieg Philip E.,Esposito Giuseppe,Lawton Michael T.,Griessenauer Christoph J.,Winkler Peter A.
Abstract
BackgroundArterial vasospasm has been ascribed as the responsible etiology of delayed cerebral infarction in patients with aneurysmal subarachnoid hemorrhage (aSAH), but other neurovascular structures may be involved. We present the protocol for a multicenter, prospective, observational study focused on analyzing morphological changes in cerebral veins of patients with aSAH.Methods and AnalysisIn a retrospective arm, we will collect head arterial and venous CT angiograms (CTA) of 50 patients with aSAH and 50 matching healthy controls at days 0–2 and 7–10, comparing morphological venous changes. A multicenter prospective observational study will follow. Patients aged ≥18 years of any gender with aSAH will be enrolled at 9 participating centers based on the predetermined eligibility criteria. A sample size of 52 aSAH patients is expected, and 52 healthy controls matched per age, gender, and comorbidities will be identified. For each patient, sequential CTA will be conducted upon admission (day 0–2), at 7–10 days, and at 14–21 days after aSAH, evaluating volumes and morphology of the cerebral deep veins and main cortical veins. One specialized image collecting center will analyze all anonymized CTA scans, performing volumetric calculation of targeted veins. Morphological venous changes over time will be evaluated using the Dice coefficient and the Jaccard index and scored using the Boeckh–Behrens system. Morphological venous changes will be correlated to clinical outcomes and compared between patients with aSAH and healthy-controls, and among groups based on surgical/endovascular treatments for aSAH.Ethics and DisseminationThis protocol has been approved by the ethics committee and institutional review board of Ethikkommission, SALK, Salzburg, Austria, and will be approved at all participating sites. The study will comply with the Declaration of Helsinki. Written informed consent will be obtained from all enrolled patients or their legal tutors. We will present our findings at academic conferences and peer-reviewed journals.Approved Protocol Version and RegistrationVersion 2, 09 June 2021.
Reference40 articles.
1. The Epidemiology of Admissions of Nontraumatic Subarachnoid Hemorrhage in the United States;Rincon;Neurosurgery.,2013
2. A Multinational Comparison of Subarachnoid Hemorrhage Epidemiology in the WHO MONICA Stroke Study;Ingall;Stroke.,2000
3. Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends;de Rooij;J Neurol Neurosurg Psychiatry.,2007
4. The probability of sudden death from rupture of intracranial aneurysms: a meta-analysis;Huang;Neurosurgery.,2002
5. Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis;Nieuwkamp;Lancet Neurol.,2009
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