Efficacy of pump-controlled selective antegrade cerebral perfusion in total arch replacement: A propensity-matched analysis

Abstract

BackgroundPump-controlled selective antegrade cerebral perfusion (PC-SACP) in total arch replacement (TAR) can regulate cerebral flow accurately, which might be beneficial for cerebral protection. However, the safety of PC-SACP for TAR combined with frozen elephant trunk implantation (FET) in patients with acute Type A dissections (ATAAD) is ambiguous.MethodsA total of 192 patients with ATAAD underwent TAR at our institution from October 2019 to July 2021. The patients were divided into two groups based on PC-SACP used: PC group (SACP carried out by using a separate pump, n = 35) and Control group (SACP carried out as a traditional method, n = 157). Patients under PC-SACP were propensity-score matched to patients without PC-SACP, resulting in 35 pairs of patients.ResultsPreoperative characteristics, including age, gender, weight, and preoperative creatinine level, were similar between the two groups. Cardiopulmonary bypass time, cross-clamp time, circulatory arrest time, and minimum nasopharyngeal temperature did not differ between the two groups. However, SACP time (54 versus 40, P = 0.001) in the PC group was significantly longer than that in the Control group. The incidence of temporary neurologic dysfunction (5.7% versus 8.6, P = 0.643) showed a no significantly lower trend in the PC group compared with the Control group. Other clinical outcomes showed no significant intergroup differences.ConclusionsPC-SACP in TAR is safe and feasible and might be beneficial for avoiding brain injury caused by “luxury” perfusion.