Author:
Long Chengmin,Wang Jingru,Gan Wenjun,Qin Xinchi,Yang Ronghua,Chen Xiaodong
Abstract
Chronic wound healing remains a challenging medical problem affecting society, which urgently requires anatomical and functional solutions. Adipose-derived stem cells (ADSCs), mesenchymal stem cells with self-renewal and multiple differentiation ability, play essential roles in wound healing and tissue regeneration. The exosomes from ADSCs (ADSC-EXOs) are extracellular vesicles that are essential for communication between cells. ADSC-EXOs release various bioactive molecules and subsequently restore tissue homeostasis and accelerate wound healing, by promoting various stages of wound repair, including regulating the inflammatory response, promoting wound angiogenesis, accelerating cell proliferation, and modulating wound remodeling. Compared with ADSCs, ADSC-EXOs have the advantages of avoiding ethical issues, being easily stored, and having high stability. In this review, a literature search of PubMed, Medline, and Google Scholar was performed for articles before August 1, 2022 focusing on exosomes from ADSCs, chronic wound repair, and therapeutic potential. This review aimed to provide new therapeutic strategies to help investigators explore how ADSC-EXOs regulate intercellular communication in chronic wounds.
Funder
National Natural Science Foundation of China
Special Fund for Science and Technology Innovation Strategy of Guangdong Province
Medical Research Fund of Guangdong Province
Research Grant of Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University
Reference102 articles.
1. Anatomy, histology and immunohistochemistry of normal human skin;Kanitakis;Eur J Dermatol,2002
2. The human skin microbiome;Byrd;Nat Rev Microbiol,2018
3. The skin microbiome;Grice;Nat Rev Microbiol,2011
4. Challenges in the treatment of chronic wounds;Frykberg;Adv Wound Care,2015
5. Delivery systems of current biologicals for the treatment of chronic cutaneous wounds and severe burns;Xue;Adv Drug Delivery Rev,2018
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献