Erectile function, urinary continence and oncologic outcomes of neurovascular bundle sparing robot-assisted radical prostatectomy for high-risk prostate cancer: A systematic review and meta-analysis

Author:

Liu Yang,Deng Xian-zhong,Qin Jiao,Wen Zhi,Jiang Yu,Huang Jing,Wang Chong-jian,Chen Cai-xia,Wang Li,Li Kun-peng,Wang Jia-hao,Yang Xue-song

Abstract

BackgroundThe nerve-sparing (NS) effect of robot-assisted radical prostatectomy (RARP) on patients with a high-risk prostate cancer remains unclear. The objective of this study was to compare the urinary continence, erectile function and oncology outcomes of the nerve-sparing and non-nerve-sparing (NNS) group during RARP surgeries.MethodsWe systematically searched databases including PubMed, Embase, Cochrane Library and Web of Science to identify relevant studies published in English up to December 2022. Newcastle-Ottawa Scale (NOS) was used as a quality evaluation tool to evaluate the quality of the literature parameters involved, including urinary continence, erectile function and oncologic outcomes, which were compared using the Stata 15.1 software (StataSE, USA).ResultsA total of 8 cohort studies involving 2499 patients were included. A meta-analysis of results showed that the NS group was beneficial to the recovery of urinary continence (RR 0.46, 95%CI 0.22, 0.96; p=0.045<0.05) and erectile function (RR 0.32, 95%CI 0.16, 0.63; p=0.001<0.05) 12 months after surgeries, which showed a better oncological outcome (RR 1.31, 95%CI 1.01, 1.69; p=0.01<0.05).ConclusionsThe current study results indicate that intraoperative NS during RARP is beneficial to long-term postoperative functional recovery and tumor prognosis of patients with high-risk prostate cancers. Due to interstudy interferences, the results should be interpreted with caution.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022384647.

Publisher

Frontiers Media SA

Subject

Cancer Research,Oncology

Reference46 articles.

1. Epidemiology and prevention of prostate cancer;Gandaglia;Eur Urol Oncol,2021

2. Urologic malignancies: advances in the analysis and interpretation of clinical findings;Crocetto;Future Sci OA,2021

3. Cancer statistics, 2022;Siegel;CA Cancer J Clin,2022

4. The epidemiology of prostate cancer;Pernar;Cold Spring Harb Perspect Med,2018

5. High-risk prostate cancer in the united states, 1990-2007;Cooperberg;World J Urol,2008

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