Author:
Frommeyer Timothy C.,Rohan Craig A.,Spandau Dan F.,Kemp Michael G.,Wanner Molly A.,Tanzi Elizabeth,Travers Jeffrey B.
Abstract
The occurrence of non-melanoma skin cancer (NMSC) is closely linked with advanced age and ultraviolet-B (UVB) exposure. More specifically, the development of NMSC is linked to diminished insulin-like growth factor-1 (IGF-1) signaling from senescent dermal fibroblasts in geriatric skin. Consequently, keratinocyte IGF-1 receptor (IGF-1R) remains inactive, resulting in failure to induce appropriate protective responses including DNA repair and cell cycle checkpoint signaling. This allows UVB-induced DNA damage to proliferate unchecked, which increases the likelihood of malignant transformation. NMSC is estimated to occur in 3.3 million individuals annually. The rising incidence results in increased morbidity and significant healthcare costs, which necessitate identification of effective treatment modalities. In this review, we highlight the pathogenesis of NMSC and discuss the potential of novel preventative therapies. In particular, wounding therapies such as dermabrasion, microneedling, chemical peeling, and fractionated laser resurfacing have been shown to restore IGF-1/IGF-1R signaling in geriatric skin and suppress the propagation of UVB-damaged keratinocytes. This wounding response effectively rejuvenates geriatric skin and decreases the incidence of age-associated NMSC.
Funder
National Institutes of Health
U.S. Department of Veterans Affairs
Reference99 articles.
1. Tropospheric Ozone: An Emerging Environmental Stress to Skin;Thiele;Biol Chem,1997
2. Chronic Skin Fragility of Aging: Current Concepts in the Pathogenesis, Recognition, and Management of Dermatoporosis;Dyer;J Clin Aesthet Dermatol,2018
3. Aging-Like Physiological Changes in the Skin of Japanese Obese Diabetic Patients;Ibuki;SAGE Open Med,2018
4. A Review of the Role of Estrogen in Dermal Aging and Facial Attractiveness in Women;Lephart;J Cosmet Dermatol,2018
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献