Author:
Grard Marion,Chatelain Camille,Delaunay Tiphaine,Pons-Tostivint Elvire,Bennouna Jaafar,Fonteneau Jean-François
Abstract
Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-α, IFN-β…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.
Funder
Institut National de la Santé et de la Recherche Médicale
Agence Nationale de la Recherche
Ligue Contre le Cancer
Fondation ARC pour la Recherche sur le Cancer
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