Author:
Zhou Qinfeng,Liu Lianfang,Zhou Jing,Chen Yuanyuan,Xie Dacheng,Yao Yinan,Cui Dawei
Abstract
The long non-coding RNA metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was initially found to be overexpressed in early non-small cell lung cancer (NSCLC). Accumulating studies have shown that MALAT1 is overexpressed in the tissue or serum of NSCLC and plays a key role in its occurrence and development. In addition, the expression level of MALAT1 is significantly related to the tumor size, stage, metastasis, and distant invasion of NSCLC. Therefore, MALAT1 could be used as a biomarker for the early diagnosis, severity assessment, or prognosis evaluation of NSCLC patients. This review describes the basic properties and biological functions of MALAT1, focuses on the specific molecular mechanism of MALAT1 as a microRNA sponge in the occurrence and development of NSCLC in recent years, and emphasizes the application and potential prospect of MALAT1 in molecular biological markers and targeted therapy of NSCLC.
Reference89 articles.
1. Cancer Statistics, 2015;Siegel;CA Cancer J Clin,2015
2. Characteristics of Computed Tomography Perfusion Parameters in Non-Small-Cell-Lung-Cancer and Its Relationship to Histology, Size, Stage an Treatment Response;Trinidad Lopez;Clin Imaging,2018
3. Five-Year Survival and Prognostic Factors According to Histology in 6101 Non-Small-Cell Lung Cancer Patients;Molinier;Respir Med Res,2020
4. Noncoding RNAs and Myocardial Fibrosis;Thum;Nat Rev Cardiol,2014
5. Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases;Kim;Oxid Med Cell Longev,2017
Cited by
21 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献