Author:
Liu Qixin,Peng Ziheng,Shen Liangfang,Shen Lin
Abstract
BackgroundThe prognostic and clinicopathological value of Ki-67 in melanoma is controversial. The purpose of this meta-analysis was to determine the prognostic role of Ki-67 in melanoma patients.Materials and MethodsThe PubMed, Cochrane Library, Web of Science, and Embase databases were searched systematically up to April 9, 2021. We calculated the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between Ki-67 overexpression and survival outcomes. We also calculated the combined odds ratios (ORs) and 95% CIs to determine the relationship between Ki-67 expression levels and clinicopathologic parameters. All data were statistically analyzed by Stata 11.0.ResultsA total of 10 studies involving 929 patients were included in our meta-analysis. The pooled HR showed that Ki-67 overexpression was connected with poor overall survival rates (HR=2.92, 95% CI=2.17-3.91, p<0.000). However, there was no correlation between Ki-67 overexpression and the PFS (HR=0.999, 95% CI =0.958-1.041, P =0.958; I2 = 21.80%, P =0.258) or RFS (HR=1.14, 95% CI = 0.42-3.11, P =0.993; I2 = 85.00%, P =0.01) rates. Ki-67 expression levels were associated with tumor thickness, but not sex, location, ulceration or vascular invasion.ConclusionKi-67 is a useful poor prognostic indicator for melanoma patients.
Reference34 articles.
1. Vital Signs: Melanoma Incidence and Mortality Trends and Projections - United States, 1982-2030;Guy;MMWR Morb Mortal Wkly Rep,2015
2. Epidemiology of Melanoma;Bolick;Hematol Oncol Clin North Am,2021
3. The Global Burden of Melanoma: Results From the Global Burden of Disease Study 2015;Karimkhani;Br J Dermatol,2017
4. Estimated Projection of US Cancer Incidence and Death to 2040;Rahib;JAMA Netw Open,2021
5. Cancer Statistics, 2020;Siegel;CA Cancer J Clin,2020
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献