Author:
Wei Lijuan,Hou Qing,Liu Jianting,Yao Ningning,Liang Yu,Cao Xin,Sun Bochen,Li Hongwei,Xu Shuming,Cao Jianzhong
Abstract
BackgroundQi et al. recently proposed a nomogram to reveal the prognostic value of peripheral blood inflammatory indexes (named Risk) and predict overall survival (OS) in limited-stage small cell lung cancer (LS-SCLC). However, it hasn’t undergone external application so far. This study aimed to verify the role of Risk as a prognostic variable of OS and apply the nomogram externally.MethodsWe used a retrospective analysis of clinical data of 254 patients diagnosed as LS-SCLC in Shanxi Cancer Hospital from January 2015 to December 2018 to apply Qi’s nomogram externally. We also performed subgroup analysis to explore the predictive value of Risk. The model was evaluated in terms of discrimination (the area under the ROC curve (AUC ROC) and calibration (calibration plots).ResultsThe prognosis of patients with low-Risk was significantly better than those with high-Risk in our cohort (p<0.01). The AUC of 1-, 2-, and 3-year OS was 0.644, 0.666, and 0.635, respectively. The calibration curve showed a nearly ideal calibration-slope of 1-, 2-, and 3-year OS (1.00 (0.41-1.59), 1.00 (0.54-1.46) and 1.00 (0.43-1.57), respectively).ConclusionThe external application of nomogram added Risk for predicting OS in LS-SCLC patients showed a moderate-to-good performance using a cohort with different case-mix characteristics. The external application confirmed the predictive value of Risk and the usefulness of the nomogram for the prediction of OS.
Reference17 articles.
1. Current Cancer Situation in China: Good or Bad News From The 2018 Global Cancer Statistics;Feng;Cancer Commun (London England),2019
2. Cancer Statistics, 2020;Siegel;CA Cancer J Clin,2020
3. Radiation and Systemic Therapy for Limited-Stage Small-Cell Lung Cancer;Bogart;J Clin Oncol Off J Am Soc Clin Oncol,2022
4. Update on the Biology, Management, and Treatment of Small Cell Lung Cancer (Sclc);Saltos;Front Oncol,2020
5. Updated Overall Survival and Pd-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (Impower133);Liu;J Clin Oncol Off J Am Soc Clin Oncol,2021