Precise diagnosis and targeted therapy of nodal T-follicular helper cell lymphoma (T-FHCL)

Author:

Du Jun,Jin Shikai,Zhang Minghui,Fu Xuehang,Yang Jingwen,Zhang Liwen,Chen Zhenwei,Huang Zoufang,Li Weisong,Hou Jian,Wang Ting

Abstract

Nodal T-follicular helper cell lymphoma (T-FHCL) derived from T-follicular helper (Tfh) cell falls into a heterogeneous category of peripheral T-cell lymphoma (PTCL). Due to the limited number of therapeutic regimens and limited first-line efficacy, T-FHCL has a poor prognosis, and there is an urgent need for effective targeted therapies. With advancements in sequencing technologies, especially single-cell sequencing and next-generation sequencing, more specific genetic aberrations characteristic of T-FHCL can be discovered, allowing for precise molecular diagnosis and specific research on novel agents. Many biomarker-targeting agents, used either alone or in combination, have been tested, and they have generally enhanced the therapeutic outcomes of T-FHCL. Histone deacetylase inhibitors achieve significant clinical benefits in the treatment of T-FHCL, especially in combination therapy. Chimeric antigen receptor T-cell (CAR-T-cell) immunotherapies, hematopoietic stem cell transplantation, and other potential agents merit further study.

Publisher

Frontiers Media SA

Subject

Cancer Research,Oncology

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