Author:
Cascione Luciano,Aresu Luca,Baudis Michael,Bertoni Francesco
Abstract
Copy number aberrations (CNV/CNA) represent a major contribution to the somatic mutation landscapes in cancers, and their identification can lead to the discovery of oncogenetic targets as well as improved disease (sub-) classification. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma in Western Countries and up to 40% of the affected individuals still succumb to the disease. DLBCL is an heterogenous group of disorders, and we call DLBCL today is not necessarily the same disease of a few years ago. This review focuses on types and frequencies of regional DNA CNVs in DLBCL, not otherwise specified, and in two particular conditions, the transformation from indolent lymphomas and the DLBCL in individuals with immunodeficiency.
Funder
Oncosuisse
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Reference75 articles.
1. Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data;Baudis;BMC Cancer,2007
2. The landscape of somatic copy-number alteration across human cancers;Beroukhim;Nature,2010
3. Nonrandom chromosome abnormalities in lymphoma;Bloomfield;Cancer Res,1983
4. Cytogenetics of non-Hodgkin’s lymphoma;Levine;J Natl Cancer Inst Monogr,1990
5. Trisomy 12 in chronic lymphoid leukemias–a metaphase and interphase cytogenetic analysis;Döhner;Leukemia,1993
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献